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Next-generation sequencing or high-throughput sequencing (HTS) should be considered as an
enabling technology that permits unprecedented sequencing coverage, unraveling the existence
of a multitude of single nucleotide polymorphisms within a single bacterial colony (see Genome Research paper), while
preserving a genome-wide perspective. More importantly, this knowledge can be expanded by multiplexing experiments
during a single run, for providing time-series analyses or for comparing series of experimental conditions.
Alternatively, this approach permits a systematic analysis of transcripts, including detection small non-coding RNA (ncRNA).
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